Ignite is our most complete ED formula: Sildenafil 70mg for rapid, potent onset, Tadalafil 20mg for up to 36 hours of coverage, and Apomorphine 4mg, a centrally acting dopamine agonist that supports arousal at the brain level. Three mechanisms, one pill.

How is Ignite different from Mach 1?

Mach 1 is our maximum-strength dual PDE5 formula: Sildenafil plus Tadalafil. Ignite takes the same dual PDE5 base and adds Apomorphine, which works upstream on the dopamine pathways that initiate arousal. If desire and drive are part of the picture, not just blood flow, Ignite is the more complete answer.

Take one pill 30-60 minutes before anticipated activity. Sildenafil and Apomorphine act quickly for immediate support, while Tadalafil keeps you covered for up to 36 hours. Do not exceed one dose per 48 hours. Use as directed by your physician.

Is combining three medications safe?

Yes, when prescribed and monitored by a physician. Each ingredient is well-studied, and our physicians screen for contraindications and confirm the combination is appropriate for your health profile before anything ships. Dosing is personalized to you.

Do I need a prescription for Ignite?

Yes. Ignite requires a valid prescription from a US-licensed physician. OnyxMD connects you with a licensed physician through a free online assessment.

Ignite

Name: Ignite
Brand: OnyxMD
Price: 9.72 USD
Availability: InStock

4.3 out of 5 · Trustpilot reviews

One pill. Every pathway. Zero doubt.

Couple sharing a close moment in warm evening light

Starts as low as $9.72/dose

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Triple-action formula: speed, staying power, and desire

Works on body and brain: blood flow plus arousal signaling

Fast onset with up to 36 hours of coverage

Lowest per-dose price on the 18-dose plan, billed $525 every 3 months. Plans from $99/month with 6, 12, or 18 doses, available monthly, every 3 months, or as a one-time purchase. Free doctor consultation and shipping. Cancel anytime.

Prescription products require an online consultation with a healthcare provider. The featured products include compounded products which have not been approved by the FDA. The FDA does not verify the safety or effectiveness of compounded drugs.

Why Men Choose Ignite

Because a great night starts before the bedroom

Desire, Not Just Readiness

PDE5 inhibitors prepare the body. Apomorphine works on the brain circuits where arousal actually starts. Ignite is for men who want to feel the spark again, not just respond to it.

Full-Spectrum Power

Sildenafil 70mg hits fast. Tadalafil 20mg holds the line for 36 hours. Apomorphine 4mg keeps the signal strong. No other formula in our lineup covers every pathway at once.

Built for the Hardest Cases

Up to 40% of men respond incompletely to single-agent therapy. Triple-mechanism treatment is designed for exactly those cases: when one pathway is not enough, cover all three.

BACKGROUND AND HISTORY

The Science of Triple-Action Therapy

Why body + brain beats body alone

Up to 40% of men have an incomplete response to PDE5 inhibitor monotherapy. Apomorphine addresses the central arousal deficit they miss

Sildenafil 70mg provides rapid, potent peripheral onset, ideal for immediate performance needs

Tadalafil 20mg extends the effective window to 36 hours, removing timing anxiety entirely

Apomorphine 4mg acts on hypothalamic dopamine D1/D2 receptors, initiating the arousal cascade that pure PDE5 therapy does not touch

Ignite by the Numbers

Active mechanisms in one pill

30 min

Rapid onset with Sildenafil

36 hrs

Extended Tadalafil coverage

40%

Men who don't fully respond to PDE5 alone

Why Ignite Goes Further

Three pathways. One pill.

Most ED treatments work at one level: the blood vessels. PDE5 inhibitors like sildenafil and tadalafil increase blood flow by preventing the breakdown of cGMP, and they work well. But for many men, the missing piece is the signal that starts the process, not just the plumbing.

Apomorphine works upstream. By stimulating dopamine D1/D2 receptors in the hypothalamus and limbic system, the brain regions responsible for sexual motivation and arousal, it activates the central erectile pathway that pure PDE5 inhibitors do not touch. Brain signals the body, body responds.

Ignite combines all three: sildenafil for speed, tadalafil for staying power, apomorphine for drive. It is the most complete formula in the OnyxMD lineup, built for men who want every variable covered.

Why Choose OnyxMD?

See what some of our customers have to say.

So grateful to have finally found a viable solution for my challenges. A bit on the pricey side but worth every penny.

Dan

It has changed life in the bedroom and dramatically improved my relationship with my wife!

Merrill

Amazing stuff, first it works...but APO really does enhance things in an incredible way.

Navaf

The combination of medicines is just right for my sexual experience. My partner is pleased too.

Don

My sex life has NEVER been as good... It's like the fountain of youth in a melt!

Michael

So grateful to have finally found a viable solution for my challenges. A bit on the pricey side but worth every penny.

Dan

How it works

Take one pill

30-60 minutes before anticipated activity. Max one dose per 48 hours.

Brain and body engage

Apomorphine supports arousal signaling while Sildenafil drives rapid physical onset.

Coverage that lasts

Tadalafil sustains readiness for up to 36 hours. No clock-watching.

Science-backed results

We analyzed 200+ peer-reviewed studies to bring you evidence-based therapy. Here's what the research proves.

¹Melis MR, Sanna F, Argiolas A, "Dopamine, Erectile Function and Male Sexual Behavior from the Past to the Present: A Review", Brain Sci. 2022;12(7):826.

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²Porst H, et al, "Combination pharmacotherapy for ED: evidence and clinical considerations", International Journal of Impotence Research 2017.

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³Fahmy G, Hess J, "Tadalafil. In: StatPearls", StatPearls Publishing 2025.

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⁴Dhaliwal A, Gupta M, "PDE5 Inhibitors. In: StatPearls", StatPearls Publishing 2025.

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Physician-prescribed • Discreet delivery • Cancel anytime