Sermorelin
Restore your body's own growth hormone rhythm
Supports lean muscle mass
Improves recovery between workouts
Deepens sleep quality
Monthly plan. Dosing is set by your physician. Cancel anytime.
Prescription products require an online consultation with a healthcare provider. The featured products include compounded products which have not been approved by the FDA. The FDA does not verify the safety or effectiveness of compounded drugs.
Why Men Choose Sermorelin
Work with your body's own growth hormone system, not around it
Your Own Production
Sermorelin prompts your pituitary to release your own growth hormone in natural pulses. Your body's feedback loops stay intact, deciding how much to release and when.
Built Around Sleep
Growth hormone is released mostly at night, during deep sleep. A nightly dose works with that rhythm, which is why deeper, more restorative sleep is often the first change men notice.
Recovery and Lean Mass
Growth hormone drives tissue repair and body composition. Restoring more youthful output supports the recovery, training response, and lean mass that decline with age.
BACKGROUND AND HISTORY
Built on Clinical Evidence
A studied approach to age-related growth hormone decline
Growth hormone secretion declines substantially with age, affecting body composition, recovery, and sleep architecture
GHRH (1-29) administration restored GH and IGF-1 levels in older men in clinical research
Because Sermorelin works through the pituitary, GH release stays pulsatile and subject to the body's own feedback regulation
Published clinical reviews position GHRH therapy as a more physiological alternative to direct growth hormone replacement
The Sermorelin Difference
29
Amino acids, the active GHRH fragment
Nightly
One small dose before bed
100%
Your own GH, not a synthetic replacement
Rx only
Prescribed and monitored by US physicians
How Sermorelin Works
Upstream of growth hormone, not in place of it
Growth hormone isn't released in a steady stream. Your pituitary releases it in pulses, mostly at night during deep sleep, under the direction of growth hormone-releasing hormone (GHRH) from the hypothalamus. With age, that signal weakens and GH output falls, with knock-on effects on lean mass, recovery, and sleep.
Sermorelin is the active fragment of GHRH (amino acids 1-29). A nightly dose restores the upstream signal: your pituitary responds by producing and releasing your own growth hormone, which in turn raises IGF-1, the growth factor responsible for much of GH's effect on muscle and tissue repair.
This matters because the release stays pulsatile and regulated. Unlike direct HGH injections, your body's feedback loops continue to govern how much hormone circulates, which is why clinical reviews describe GHRH therapy as the more physiological approach.
Sermorelin is compounded for OnyxMD by licensed US pharmacies and prescribed only when a physician determines it's appropriate for you. Dosing is individual, set and monitored by your physician.
Why Choose OnyxMD?
See what some of our customers have to say.
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How it works
Quick Online Assessment
A few minutes about your goals, health, and history. Reviewed by a licensed physician.
Personalized Dosing
Your physician sets your dose and ships your prescription discreetly to your door.
One Dose, Nightly
A small injection before bed, timed to your natural growth hormone rhythm.
Science-backed results
We analyzed 200+ peer-reviewed studies to bring you evidence-based therapy. Here's what the research proves.
1Walker RF, "Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?", Clinical Interventions in Aging 2006. | https://doi.org/10.2147/ciia.2006.1.4.307 |
2Corpas E, Harman SM, Piñeyro MA, Roberson R, Blackman MR, "Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men", Journal of Clinical Endocrinology & Metabolism 1992. | https://doi.org/10.1210/jcem.75.2.1379256 |
Ready to get started with Sermorelin?
Free online assessment. Physician-prescribed. Shipped discreetly to your door.
Get startedPhysician-prescribed • Discreet delivery • Cancel anytime